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Bubles
2023.02.28
SCIENCE

A research paper on a stable postal test method for blood glycated albumin has been published in Clinica Chimica Acta.

We developed a stable glycated albuminl testing method using only 10 ?l of blood mailed by normal posting service.

Glycated Albumin can be used as an indicator of weekly average blood glucose. However, currently, the test requires an in-patient blood collection, which poses challenges in terms of visiting costs and invasiveness.
To solve this problem, our research group has developed a stable method for simple and minimally invasive postal testing, whereby users can collect as little as 10 ?l of blood from their fingertips at home and post it to a post box.
The results of this research have been published in Clinica Chimica Acta.
Aihara M, Irie T, Yasukawa K, et al. Development of a high-performance liquid chromatographic glycated albumin assay using finger-prick blood samples [published online ahead of print, 28 Feb 2023]. Clin Chim Acta. 2023;542:117272. doi:10.1016/j.cca.2023.117272
This research was funded by AMED in collaboration with the University of Tokyo Hospital and Jinnouchi Hospital.
Provigate aims to realize the clinical use of the home GA monitoring method soon based on this postal testing method.

https://doi.org/10.1016/j.cca.2023.117272

People may think of glucose monitoring as simple as this: "Diabetes is a disease of blood sugar. This is why people with diabetes use glucometer."
However, it's not that simple. Blood sugar measurement has diverse objectives, including diagnosing diabetes, dosing self-injection of insulin, avoiding hypoglycemia due to excessive drug efficacy, and behavior change.
You must choose the appropriate blood sugar measurement method for your purpose.

There are two types of self-blood glucose measurement methods: SMBG (Self-Monitoring of Blood Glucose), which is widely used, and CGM (Continuous Glucose Monitoring), which has become popular in recent years.
These two blood glucose measurement methods are designed mainly for patients who self-inject insulin and other injectable drugs.
Until now, there has been no simple and daily method for measuring blood glucose at home other than these two methods.

Some drugs, such as insulin, are very potent and can cause dangerous hypoglycemia if the dosage is incorrect.
Therefore, for example, those who use insulin must measure their blood glucose accurately before self-injection at home and carefully determine the dose.
After injection, if there are signs of hypoglycemia, it is necessary to measure blood glucose immediately. If necessary, you need to take some sugar to avoid hypoglycemia.
However, both methods have an issue with invasiveness. In addition, they cost a lot. CGM costs at least $60 and needs to be replaced every two weeks, which is also a significant economic burden. SMBG requires frequent measurements, so the total cost becomes significant when accumulated.
Unfortunately, SMBG and CGM are not suitable for everyone due to invasiveness and cost.

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